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Common Opioid Withdrawal Symptoms

Medically Reviewed by
Alice Roque, FNP, CARN-AP
October 11, 2024

Opioid withdrawal is a natural response to the cessation of opioid use. The duration and severity of symptoms vary depending on various factors, including the type of opioid, the dosage, and the duration of use.

Withdrawal is challenging, often painful and potentially dangerous. If you or someone you love is going through withdrawal, contacting a doctor for treatment and support is strongly encouraged. Rehabilitation programs like Eleanor Health can help you handle withdrawal and transition into a recovery program.

What Is Opioid Withdrawal?

Opioid withdrawal refers to the array of symptoms that occur when you abruptly stop or significantly reduce your intake of opioid drugs after developing physical dependence. As your body adjusts to the absence of these substances, it triggers a series of unpleasant physical and psychological reactions.

Opioid Withdrawal Symptoms

Opioid withdrawal symptoms can vary in severity, depending on the specific opioid, the duration of use, and individual factors. Many milder symptoms can be treated at home, but serious symptoms require immediate medical attention. Common opioid withdrawal symptoms include:

  • Muscle aches and pains
  • Nausea and vomiting
  • Diarrhea
  • Sweating
  • Runny nose
  • Anxiety and irritability
  • Insomnia and restlessness
  • Fever and chills
  • Dilated pupils
  • Goosebumps

These symptoms can be both physically and emotionally distressing, making it challenging to cope with the withdrawal process without professional support. The duration of opioid withdrawal symptoms can also vary significantly. 

How Long Does Withdrawal Last?

Withdrawal symptoms of short-acting opioids (like heroin, codeine, or oxycodone) typically begin within 8-24 hours after the last dose and peak within 1-3 days. The acute withdrawal phase can last up to 7-10 days, with residual symptoms potentially persisting for weeks or months.

For long-acting opioids (such as methadone or buprenorphine) withdrawal symptoms may take longer to appear, usually within 24-48 hours after the last dose. The acute withdrawal phase can last up to 10-20 days, and, similar to short-acting opioids, residual symptoms can last several weeks or months.

A timeline of opioid withdrawal symptoms

Opioid Withdrawal Timeline

The opioid withdrawal timeline is different for each person, but withdrawal can be generally split into three stages of progression: early, peak, and late.

Early Stage: Mild Symptoms Start

The early stage of opioid withdrawal typically begins within 6 to 12 hours after the last dose of a short-acting opioid or 24 to 36 hours after the last dose of a long-acting opioid. During this stage, you may experience mild symptoms such as:

  • Anxiety
  • Restlessness
  • Muscle aches
  • Increased heart rate
  • Sweating

Additionally, intense cravings for opioids can occur, making it challenging to resist the urge to use again.

Peak Stage: Onset of Intense Symptoms

The peak stage of opioid withdrawal is often the most challenging and intense phase. It typically occurs within 72 hours after the last dose of a short-acting opioid or 4 to 6 days after the last dose of a long-acting opioid. During this stage, you may experience a wide range of severe symptoms, including:

  • Nausea and vomiting
  • Diarrhea
  • Abdominal cramps
  • Muscle spasms
  • Chills and goosebumps
  • Intense cravings

These symptoms can be extremely uncomfortable and may require medical intervention to manage effectively.

Late Stage: Gradual Improvement of Symptoms

The late stage of opioid withdrawal typically begins after the peak stage, around 5 to 7 days after the last dose of a short-acting opioid or 7 to 10 days after the last dose of a long-acting opioid. During this stage, the physical symptoms gradually subside, but psychological symptoms, such as depression, anxiety, and cravings, may persist.

The duration of this stage can vary widely, with some individuals experiencing lingering symptoms for several weeks or even months after the initial withdrawal period.

Quitting Opioids Safely

Opioid use disorder (OUD) is a medical condition that changes your brain chemistry and affects the body. It’s not a moral failure, and it’s not something you can just quit “with enough willpower”. Effective treatment for OUD typically involves a combination of approaches to help you get better, including:

Medication-Assisted Treatment for Opioids:

Behavioral Therapies:

  • Cognitive-behavioral therapy (CBT)
  • Contingency management
  • Motivational interviewing

Support Groups & Peer Support:

  • Community Recovery Partners (CRPs)
  • Narcotics Anonymous (NA)
  • SMART Recovery

The specific treatment plan is tailored to the individual’s needs, taking into account the severity of the addiction, co-occurring mental health conditions, and personal preferences. If you are going through withdrawal or just need help with your opioid use disorder, Eleanor Health can help. Learn more about our virtual opioid addiction treatment services.

Common Questions About Opioid Withdrawal

Are Opioid Withdrawals Deadly?

While opioid withdrawal is not typically life-threatening on its own, it can be extremely uncomfortable and challenging to manage without proper medical supervision. In rare cases, severe dehydration or complications from vomiting and diarrhea can lead to dangerous situations if left untreated. If your symptoms are severe, seek medical help immediately.

What Medications Help With Opioid Withdrawal?

Several medications can help manage opioid withdrawal symptoms and increase the chances of successful recovery. It’s essential to consult with a healthcare professional to determine the most appropriate medication regimen for your specific situation. In some cases, over the counter medication can help manage withdrawal symptoms, but prescription medications might be required to address the more severe ones.

Besides Buprenorphine, Naltrexone and methadone, medications used to manage withdrawal include:

  • Clonidine: This non-opioid medication can help alleviate specific withdrawal symptoms like muscle aches, anxiety, and sweating.
  • Anti-nausea medications: Medications like ondansetron can help manage nausea and vomiting associated with opioid withdrawal.
  • Loperamide: This over-the-counter medication can help reduce diarrhea during withdrawal.

Can I go to the ER for Opioid Withdrawal?

Yes, you can seek help at the emergency room (ER) if you are experiencing severe opioid withdrawal symptoms that are difficult to manage on your own. The ER can provide immediate medical attention, medication management, and referrals to appropriate treatment facilities or programs.

However, it’s important to note that the ER is typically designed to address acute medical emergencies, and long-term opioid withdrawal management may be better handled through specialized addiction treatment programs or outpatient clinics like Eleanor Health.

Alice Roque, FNP, CARN-AP

Alice is a board-certified Family Nurse Practitioner and Addiction Registered Nurse - Advanced Practice. With a background in communications and gender studies from Tulane University, Alice transitioned to nursing shortly after Hurricane Katrina, driven by a desire to make a meaningful impact in healthcare in her community. She earned her Bachelor of Science in Nursing from the University of Louisiana at Lafayette and her Master of Science in Nursing from Loyola University New Orleans. Over the years, Alice has gained invaluable experience in both academic and clinical settings, but will emphasize that her most profound lessons come from direct communication and interaction with her patients, their families, and the communities they serve. Alice currently serves as a regional medical leader at Eleanor Health and enjoys being a part of a dynamic team that provides compassionate, accessible, and equitable care.

Medication Guide Addiction & recovery Blog

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